_1689490364 20230716065244000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Small Animal Advances Small Anim. Adv. 2821-2363 06 25 2023 2 2 Paa Kobina Turkson https://orcid.org/0000-0002-5319-2021 Introduction: The overuse, misuse, or abuse of antimicrobials in pets has the potential to result in antimicrobial resistance in pathogens of animal origin. There is a need for prudent use of antimicrobials to prevent this issue. The objective of the present study was to evaluate the trend of antimicrobial use in small animals at a veterinary practice in Accra, Ghana, over the period of 2015 to 2021. Materials and methods: Clinical records of 4324 animal patients presented to a veterinary hospital in Ghana that were given antimicrobials from September 2015 to December 2021 were analyzed for frequencies, proportions, and statistical differences. The gender of animals involved in this study were 53.1% males, 43.4% females, and 3.4% did not have the sex stated. The perceptions of antimicrobials by veterinarians and prescription patterns (to understand the basis for the prescription patterns) were considered in this study. Results: Antimicrobial use increased significantly from 56% in the first period (September 2015 to December 2017) to 75% in 2020, dropping to 59% in 2021. The prescription diversity was calculated to be 0.82. The most common indicator for antimicrobial use was a complex of symptoms and signs of anorexia-vomiting-diarrhea (27%). The number of antimicrobials prescribed per visit ranged from 1 to 5. The penicillin type (34%), tetracyclines (26.4%), sulphonamides (18.9%), and nitroimidazoles (10.6%) were the most used antimicrobial group. The routes and dosages administered were recorded in 70.3% and 92% of cases, respectively. The intramuscular route (54.5%) was the most preferred administration method by the clinicians. Notably, 95% of the veterinarians were neither aware of nor used any prescription guidance protocol in the small animal veterinary facility. Conclusion: Antimicrobials were used in high proportions in pets (mainly dogs) from 2015 to 2021. Penicillin, tetracyclines, and sulphonamides were more commonly used. Detailed information on antimicrobial prescriptions and use in a small animal veterinary practice setting in Ghana could provide valuable data for providing guidelines in antibacterial usage. 06 25 2023 12 25 https://creativecommons.org/licenses/by/4.0 10.58803/saa.v2i2.13 https://saa.rovedar.com/index.php/SAA/article/view/13 https://saa.rovedar.com/index.php/SAA/article/download/13/26 https://saa.rovedar.com/index.php/SAA/article/download/13/26 Beyene T, and Tesega B. Rational veterinary drug use: Its significance in public health. J Vet Med Anim Health. 2014; 6(12): 302-308. DOI: 10.5897/JVMAH2014.0332 10.58803/rbes.v1i2.7 10.1016/B978-0-7020-7167-6.00051-8 10.2147/IDR.S173867 10.4102/jsava.v92i0.2120 10.4103/0253-7613.25802 Bbosa GS, and Mwebaza N. Global irrational antibiotics/antibacterial drugs use: Current and future health consequences. Microbiology. 2013; 3(4): 1645-1655. 10.1155/2014/541340 10.1093/jac/dkh332 10.1111/j.1439-0450.2004.00784.x 10.1111/j.1748-5827.2011.01072.x 10.1016/j.tcam.2021.100540 Nwiyi PO. Choice and pattern of therapeutic antimicrobials in companion animals (dogs, cats and birds) in Afia, Abia State, Nigeria. Online J Anim Feed Res. 2014; 4(2): 29-31. Available at: https://www.ojafr.ir/main/attachments/article/102/Online%20J.%20Anim.%20Feed%20Res.,%204(2)%2029-31.pdf 10.3390/antibiotics11070885 10.4172/2157-7579.1000319 10.1016/j.jgar.2020.03.009 Adeapena W, Afari-Asiedu S, Najjemba R, Griensven Jv, Delamou A, Ohene Buabeng K, et al. Antibiotic use in a municipal veterinary 10.3390/tropicalmed6030138 10.2307/2529310 10.1016/j.cimid.2021.101640 Singleton DA, Sanchez-Vizcario F, Dawson S, Jones PH, Noble PJM, Pinchbeck GL, et al. Patterns of antimicrobial agent prescription in a sentinel population of canine and feline veterinary practices 10.1016/j.tvjl.2017.03.010 10.3389/fvets.2021.689018 Rogers O. The importance of data sharing for veterinarians. ; DOI: https://faunalytics.org/the-importance-of-data-sharing-for-veterinarians/# Turkson PK. Use of drugs and antibiotics in poultry production 10.4314/gjas.v41i1.46142 10.1111/j.1365-3156.2012.02955.x 10.4172/2472-1212.1000120 10.1071/AN16832 10.1371/journal.pone.0220274 Nkansa M, Agbekpornu H, Kikimoto BB, and Chandler CIR. Antibiotic use among poultry farmers in the Dormaa Municipality, Ghana. Report for Fleming Fund Fellowship Programme. Project report. London School of Hygiene & Tropical Medicine. 2020. DOI: 10.17037/PUBS.04658868 Ihedioha TE, Asuzu IU, and Nwanta JE. Trends in the clinical use of antibiotics in a veterinary hospital in Nigeria, 2013-2017. Thai J Vet Med. 2020; 50(4): 487-494. Available at: https://digital.car.chula.ac.th/tjvm/vol50/iss4/6?utm_source=digital.car.chula.ac.th%2Ftjvm%2Fvol50%2Fiss4%2F6&utm_medium=PDF&utm_campaign=PDFCoverPages Ebbo AA, Agaie MB, Adamu U, Deneji AI, and Garba HS. Retrospective analysis of cases presented to the veterinary teaching hospital, Usmanu Danfodiyo University Sokoto (1993 - 2002). Niger Vet J. 2003; 24(3): 133-136. 10.4314/nvj.v32i1.68994 10.5455/javar.2015.b115 10.1016/j.rvsc.2022.07.028 10.3329/bjvm.v13i2.26629 10.1016/j.prevetmed.2016.11.017 10.17582/journal.rjvp/2019/7.2.53.57 10.1016/j.prevetmed.2021.105471 American veterinary medical association (AVMA). Pet ownership and demographic source book. 2018. Available at: https://www.avma.org/sites/default/files/resources/AVMA-Pet-Demographics-Executive-Summary.pdf Robinson RJ, Dean RS, Cobb MJ, and Brennan ML. Investigating common clinical presentations in first opinion consultations 10.1136/vr.102751 Robbins SN, Goggs R, Lhermie G, Lalonde-Paul DF, and Manard J. Antimicrobial prescribing practies in small animal emergency 10.3389/fvets.2020.00110 10.1136/vr.103830 10.1111/zph.12979 10.1111/jvim.16314 10.1111/j.1532-950X.1988.tb00278.x 10.1097/00001432-200406000-00003 10.2147/TCRM.S87789 10.1136/vr.101454 10.1371/journal.pone.0223534 10.1136/vr.103916 10.1111/jvim.15083 10.1016/j.prevetmed.2014.05.007 10.1023/A:1010381426475 10.3389/fvets.2021.558973 Kamwanja LA, Sake J, Awotedu A, Fute I, and Ndomondo-Sigonda M. Situation analysis study on medicines registration harmonisation in Africa. Final report for the economic community of West African States (ECOWAS). Midrand, South Africa: African Union Development Agency (AUDA-NEPAD); 2011. 10.1186/s12889-017-4910-7 10.1177/003335491212700103 10.1126/science.aaw1944 10.1136/vr.155.9.259 10.1136/vr.104316 10.3390/ani11020348 10.3390/antibiotics9080453 10.30954/2277-940X.05.2019.6 Federal ministries of agriculture, environment and health (FMAEH). Antimicrobial use and resistance in Nigeria: Situation analysis and recommendations. Abuja, Nigeria: 2017. p. 80-82. Kaba S, Konan BA, Atto V, and Datte JY. Monitoring of the use of veterinary medicines containing antibiotics in Côte d’Ivoire in 2013. J Vet Med Animal Sci. 2020; 3(1): 1033. Available at: https://meddocsonline.org/journal-of-veterinary-medicine-and-animal-sciences/monitoring-of-the-use-of-veterinary-medicines-containing-antibiotics-in-2013.pdf 10.5772/intechopen.84888 10.2147/IDR.S21769 10.1111/jocn.13445 American association for the advancement of science (AAAS). Veterinary clinical record keeping guidelines., Washington DC, USA: American Association for the Advancement of Science; 2018. p. 3. 10.1093/jac/dkq543 European medicines agency. Reflection paper on the risk of antimicrobial resistance transfer from companion animals. p. 1-25. Available at: https://www.ema.europa.eu/en/documents/scientific-guideline/reflection-paper-risk-antimicrobial-resistance-transfer-companion-animals_en.pdf 10.3389/fvets.2018.00309 10.18773/austprescr.2013.045 Centers for disease control and prevention (CDC). Core elements of antibiotic stewardship. Antibiotic prescribing and use. Available at: https://www.cdc.gov/antibiotic-use/core-elements/index.html 10.1016/j.ijmm.2006.01.059 10.58803/rbes.v1i1.5 10.2460/javma.228.4.553