_1689231769 20230713070249000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Small Animal Advances Small Anim. Adv. 2821-2363 06 25 2023 2 2 Ali Jahanmahin Hassan Borji https://orcid.org/0000-0003-4706-4995 Toxocariasis is a zoonotic disease caused by the parasite Toxocara canis, with significant effects on human health. This article provided a comprehensive overview of the importance of complications of Toxocara canis infection. The introduction highlighted the relevance of zoonotic diseases and introduced toxocariasis as a specific example. The subsequent sections delved into toxocariasis, covering its transmission, lifecycle, host specificity, and primary sources of human infection. The epidemiology section presented the global prevalence and distribution of toxocariasis at 11.1% (95% CI: 10.6–11.7%), emphasizing high-risk groups and geographical factors contributing to illness. Detailed information was provided regarding the clinical manifestations of toxocariasis, including variations in disease severity and potential complications. Symptoms of visceral toxocariasis include fever, fatigue, coughing, wheezing, or abdominal pain. The diagnostic methods include laboratory methods (serological testing and western blot) and molecular techniques (PCR), and clinical methods (chest X-ray and CT scan). The prevention and control section outlined strategies for prevention, highlighting the significance of public health measures and awareness campaigns. The One Health approach has recognized the interconnections between human, animal, and environmental health. It has highlighted the necessity of cooperative actions to prevent the spread of diseases that can be transmitted between animals and humans. Future directions need to highlight ongoing research and advancements, including improved diagnostic tools, targeted therapies, risk assessment, and international collaboration. The conclusion reinforces the importance of understanding and addressing Toxocara canis infection on human health. Adopting a One Health approach and implementing effective prevention, diagnosis, and treatment strategies can reduce the burden of toxocariasis, leading to improved health outcomes for humans and animals. 06 25 2023 5 11 https://creativecommons.org/licenses/by/4.0 10.58803/saa.v2i2.14 https://saa.rovedar.com/index.php/SAA/article/view/14 https://saa.rovedar.com/index.php/SAA/article/download/14/22 https://saa.rovedar.com/index.php/SAA/article/download/14/22 10.58803/fahn.v1i2.10 10.4274/tpd.galenos.2020.6985 10.1007/s11686-023-00680-3 Sadr S, Charbgoo A, Borji H, and Hajjafari A. Interactions between innate immunity system and Echinococcus granulosus: Permission for vaccine development. Series Med Sci. 2022; 3(1): 1-18. Available at: https://profdoc.um.ac.ir/articles/a/1092954.pdf 10.54203/scil.2023.wvj7 10.1016/j.onehlt.2021.100301 Shahrokhi A, Moradpour N, Siahsarvie R, and Borji H. An investigation of potentially zoonotic helminth parasites of allactaga elater in Sarakhs, Iran. J Lab Anim Res. 2022; 1(1): 8-13. Available at: https://jlar.rovedar.com/index.php/JLAR/article/view/7 10.1016/j.parepi.2022.e00245 10.1017/S0031182021001591 10.1016/bs.apar.2020.01.001 10.1128/CMR.00266-20 10.1053/j.tcam.2019.04.001 10.1016/j.parepi.2021.e00232 10.1016/j.vprsr.2019.100362 10.1016/j.prevetmed.2021.105385 10.2478/s11686-019-00166-1 10.1007/978-3-030-53230-7_2 10.1016/j.meegid.2019.104002 10.1371/journal.pntd.0007809 Kaul P, Wright I, and Elsheikha H. Soil contamination with Toxocara spp. eggs in public parks in the Midlands. Vet Nurse. 2022; 13(8): 383-391. Available at: https://www.theveterinarynurse.com/research/article/soil-contamination-with-toxocara-spp-eggs-in-public-parks-in-the-midlands 10.22579/20112629.631 10.1016/j.vaccine.2021.12.052 10.21521/mw.6436 Haji Mohammadi K, Heidarpour M, Moosavi Z, and Borji H. Histopathological and biochemical evaluation of albendazole in the treatment of infected mice with hydatid cyst. J Lab Anim Res. 2022; 1(1): 1-7. Available at: https://jlar.rovedar.com/index.php/JLAR/article/ view/6 Zheng WB, Zou Y, Elsheikha HM, Liu GH, Hu MH, Wang SL, et al. Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis. Parasit Vectors. 2019; 12: 447. DOI: 10.1186%2Fs13071-019-3703-5 10.1128/CMR.16.2.265-272.2003 10.1016/S1473-3099(17)30331-6 10.18683/germs.2018.1143 10.14202/vetworld.2015.946-957 Sowemimo OA, Lee YL, Asaolu SO, Chuang TW, Akinwale OP, Badejoko BO, et al. Seroepidemiological study and associated risk factors of Toxocara canis infection among preschool children in Osun 10.1016/j.actatropica.2017.05.030 10.1186/s12879-020-4759-8 10.1016/j.vetpar.2016.12.011 10.1186/s13071-015-0875-5 Hajipour N. A survey on the prevalence of Toxocara cati, Toxocara canis and Toxascaris leonina eggs in stray dogs and cats’ faeces in Northwest of Iran: A potential risk for human health. Trop Biomed. 2019; 36(1): 143-151. Available at: https://pubmed.ncbi.nlm.nih.gov/33597434/ 10.1186/s40249-018-0437-0 10.1016/j.envpol.2018.07.087 10.1007/s00436-015-4736-0 10.1155/2016/1715924 10.1017/S0031182015001407 10.17352/2455-5363.000016 10.1007/s00436-016-5139-6 10.2478/s11686-019-00121-0 10.1021/acs.est.7b02811 10.3390/ijerph17217914 10.7705/biomedica.v38i0.3684 10.1007/s12639-014-0532-5 10.1371/journal.pntd.0005818 10.1017/S0950268814003665 10.1371/journal.pntd.0008249 10.1016/bs.apar.2020.01.027 10.1016/bs.apar.2020.01.011 Qaemifar N, Borji H, and Adhami G. The antiparasitic properties of allium sativum: Can it be used as a complementary treatment for echinococcosis?. J Lab Anim Res. 2023; 2(1): 1-5. Available at: https://jlar.rovedar.com/index.php/JLAR/article/view/14 Weller PF, and Leder K. Toxocariasis: Visceral and ocular larva migrans. Available at: https://www.uptodate.com/contents/toxocariasis-visceral-and-ocular-larva-migrans 10.1155/2017/4368659 10.1016/j.actatropica.2015.11.003 10.1016/j.pt.2021.12.006 10.4254/wjh.v8.i18.757 10.3892/etm.2021.9953 10.1128/CMR.00106-14 10.1017/S0031182020002085 10.1002/jcla.21844 10.1016/bs.apar.2020.01.004 10.1002/9781119021872.ch15 10.5603/PiAP.a2015.0043 10.1016/bs.apar.2020.03.001 10.1016/j.rvsc.2020.12.017 10.1128/CMR.00044-15 10.1007/s12639-022-01525-y Abbasi AM, Eftekhari Hasan Abad MR, and Saeed M. The role of mesenchymal stem cell therapy in echinococcus granulosus treatment: A prospective review. J Lab Anim Rese, 2023; 2(2): 6-10. Available at: https://jlar.rovedar.com/index.php/JLAR/article/view/15 10.1111/zph.12280 10.1016/j.actatropica.2015.03.018 10.1007/s12639-013-0402-6