_1776568496 20260419031456000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Small Animal Advances Small Anim. Adv. 2821-2363 03 05 2026 5 1 Muhammad Hanzalah Yousaf https://orcid.org/0009-0005-7241-5701 Umar Aziz https://orcid.org/0009-0009-6266-4340 Abdul Rehman https://orcid.org/0009-0009-3221-2984 Muhammad Waqar https://orcid.org/0009-0001-0172-9739 Nimra Safdar Ali https://orcid.org/0009-0000-6141-0917 Nauman Khan https://orcid.org/0009-0008-1289-6859 Muhammad Mohsin https://orcid.org/0009-0004-8057-9303 Muhammad Yahya Maarij https://orcid.org/0009-0003-1031-2964 Muhammad Mushahid https://orcid.org/0000-0001-8670-3011 Xiaopeng An Lipids are essential for animal physiology; however, dysregulated lipid metabolism can induce metabolic stress and impair growth, development, and reproduction. Metabolic homeostasis depends on endocrine-immune system interactions, yet how lipid droplets and organelles, such as the endoplasmic reticulum, mitochondria, lysosomes, and peroxisomes, contribute to stress‑induced lipid dysregulation remains unclear. The present study aimed to synthesize current evidence on redox-mediated regulation of lipid metabolism and lipid metabolic disorders in animals, highlighting recent advances, and identify key directions for future studies. The present study summarized evidence on how different dietary lipid classes influence metabolism and animal health, as well as the role of bioactive nutrients in metabolic programming. The current study described the endocrine functions of the liver, gut, and adipose tissue, as well as the stress-related interactions among these organs. The present study indicated how lipid droplets engaged in dynamic organelle interactions during stress progression and evaluated the potential of lipid‑focused nutritional interventions as personalized mitigation strategies. In addition, gut microbiota-derived metabolites and related pathways that contribute to redox imbalance, organelle dysfunction, and stress-associated lipid dysregulation were explored. The current study demonstrated that stress-induced disruptions in lipid metabolism involve intricate, multi-organ, and multi-organelle mechanisms driven by redox changes. 03 31 2026 5 15 https://creativecommons.org/licenses/by/4.0 10.58803/saa.v5i1.47 https://saa.rovedar.com/index.php/SAA/article/view/47 https://saa.rovedar.com/index.php/SAA/article/download/47/69 https://saa.rovedar.com/index.php/SAA/article/download/47/69 Abou-Rjeileh U, El-Yazbi AF, and El-Sibai M. Redox regulation of lipid mobilization in adipose tissues. Antioxidants. 2021; 10(7): 1090. DOI: 10.3390/antiox10071090 Fransen M, and Lismont C. Redox signaling from and to peroxisomes: Progress, challenges, and prospects. Antioxid Redox Signal. 2019; 30(1): 95-112. DOI: 10.1089/ars.2018.7515 Araújo AC, Wheelock CE, and Haeggström JZ. The eicosanoids, redox-regulated lipid mediators in immunometabolic disorders. Antioxid Redox Signal. 2018; 29(3): 275-296. DOI: 10.1089/ars.2017.7332 Serrano A, Ribot J, Palou A, Bonet ML. Long-term programming of skeletal muscle and liver lipid and energy metabolism by resveratrol supplementation to suckling mice. J Nutr Biochem. 2021; 95: 108770. DOI: 10.1016/j.jnutbio.2021.108770 Patias NS, de Queiroz EAIF, Ferrarini SR, Bomfim GF, Aguiar DH, Sinhorin AP, et al. Effect of liposomal Protium heptaphyllum (Alb.) march extract in the treatment of obesity induced by high-calorie diet. Biology. 2024; 13(7): 535. DOI: 10.3390/biology13070535 Chen Z, Tian R, She Z, Cai J, and Li H. Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. Free Radic Biol Med. 2020; 152: 116-141. DOI: 10.1016/j.freeradbiomed.2020.02.025 Li PL, and Zhang Y. Cross talk between ceramide and redox signaling: Implications for endothelial dysfunction and renal disease. Handb Exp Pharmacol. 2013; 216: 171-197. DOI: 10.1007/978-3-7091-1511-4_9 Higdon A, Diers AR, Oh JY, Landar A, and Darley-Usmar VM. Cell signalling by reactive lipid species: New concepts and molecular mechanisms. Biochem J. 2012; 442(3): 453-464. DOI: 10.1042/BJ20111752 Niki E. Lipid peroxidation: physiological levels and dual biological effects. Free Radic Biol Med. 2009; 47(5): 469-484. DOI: 10.1016/j.freeradbiomed.2009.05.032 Forman HJ. Redox signaling: An evolution from free radicals to aging. Free Radic Biol Med. 2016; 97: 398-407. DOI: 10.1016/j.freeradbiomed.2016.07.003 Yadav UC, and Ramana KV. Regulation of NF-κB-induced inflammatory signaling by lipid peroxidation-derived aldehydes. Oxid Med Cell Longev. 2013; 2013: 690545. DOI: 10.1155/2013/690545 Distéfano AM, López GA, Bauer V, Zabaleta E, and Pagnussat GC. Ferroptosis in plants: Regulation of lipid peroxidation and redox status. Biochem J. 2022; 479(7): 857-866. DOI: 10.1042/BCJ20210682 Clérin E, Aït-Ali N, Sahel JA, and Léveillard T. Restoration of rod-derived metabolic and redox signaling to prevent blindness. Cold Spring Harb Perspect Med. 2024; 14(11): a041284. DOI: 10.1101/cshperspect.a041284 Ushio-Fukai M. Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal. 2009; 11(6): 1289-1299. DOI: 10.1089/ars.2008.2333 Circu ML, and Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med. 2010; 48(6): 749-762. DOI: 10.1016/j.freeradbiomed.2009.12.022 Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: What is the clinical significance? Hypertension. 2004; 44(3): 248-252. DOI: 10.1161/01.HYP.0000138070.47616.9d Brigelius-Flohé R, and Flohé Ll. Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal. 2011; 15(8): 2335-2381. DOI: 10.1089/ars.2010.3534 Morgan MJ, and Liu ZG. Lipid rafts and oxidative stress-induced cell death. Antioxid Redox Signal. 2007; 9(9): 1471-1483. DOI: 10.1089/ars.2007.1658 Ježek P. Physiological fatty acid-stimulated insulin secretion and redox signaling versus lipotoxicity. Antioxid Redox Signal. 2025; 42(10-12): 566-622. DOI: 10.1089/ars.2024.0799 Thomas SR, Maiocchi S, Taylor WR, Cai H, and Thomas DD. Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal. 2008; 10(10): 1713-1765. DOI: 10.1089/ars.2008.2027 Tai CC, and Ding ST. N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: Mechanisms and implications for obesity prevention. J Nutr Biochem. 2010; 21(5): 357-363. DOI: 10.1016/j.jnutbio.2009.09.010 Bergen WG, and Mersmann HJ. Comparative aspects of lipid metabolism: Impact on contemporary research and use of animal models. J Nutr. 2005; 135(11): 2499-2502. DOI: 10.1093/jn/135.11.2499 Ringseis R, and Eder K. Regulation of genes involved in lipid metabolism by dietary oxidized fat. Mol Nutr Food Res. 2011; 55(1): 109-121. DOI: 10.1002/mnfr.201000424 Bergen WG, and Brandebourg TD. Regulation of lipid deposition in farm animals: Parallels between agriculture and human physiology. Exp Biol Med (Maywood). 2016; 241(12): 1272-1280. DOI: 10.1177/1535370216654996 Wang YM, Zhang B, Xue Y, Li ZJ, Wang JF, Xue CH, et al. The mechanism of dietary cholesterol effects on lipids metabolism in rats. Lipids Health Dis. 2010; 9: 4. DOI: 10.1186/1476-511X-9-4 Hulbert AJ, Turner N, Storlien LH, and Else PL. Dietary fats and membrane function: Implications for metabolism and disease. Biol Rev Camb Philos Soc. 2005; 80(1): 155-169. DOI: 10.1017/s1464793104006578 Ding X, Giannenas I, Skoufos I, Wang J, and Zhu W. The effects of plant extracts on lipid metabolism of chickens – A review. Anim Biosci. 2023; 36(5): 679-691. DOI: 10.5713/ab.22.0272 Ko CW, Qu J, Black DD, and Tso P. Regulation of intestinal lipid metabolism: Current concepts and relevance to disease. Nat Rev Gastroenterol Hepatol. 2020; 17(3): 169-183. DOI: 10.1038/s41575-019-0250-7 Zhang W, Dan Z, Zheng J, Du J, Liu Y, Zhao Z, et al. Optimal dietary lipid levels alleviated adverse effects of high temperature on growth, lipid metabolism, antioxidant and immune responses in juvenile turbot (Scophthalmus maximus L.). Comp Biochem Physiol B Biochem Mol Biol. 2024; 272: 110962. DOI: 10.1016/j.cbpb.2024.110962 Scollan ND, Dannenberger D, Nuernberg K, Richardson I, MacKintosh S, Hocquette JF, et al. Enhancing the nutritional and health value of beef lipids and their relationship with meat quality. Meat Sci. 2014; 97(3): 384-394. DOI: 10.1016/j.meatsci.2014.02.015 Jin A, Kan Z, Tan Q, Shao J, Han Q, Chang Y, et al. Supplementation with food-derived oligopeptides promotes lipid metabolism in young male cyclists: A randomized controlled crossover trial. J Int Soc Sports Nutr. 2023; 20(1): 2254741. DOI: 10.1080/15502783.2023.2254741 Chilliard Y, and Ferlay A. Dietary lipids and forages interactions on cow and goat milk fatty acid composition and sensory properties. Reprod Nutr Dev. 2004; 44(5): 467-492. DOI: 10.1051/rnd:2004052 Navidshad B, and Royan M. Effect of dietary fat on gene expression in poultry, a review. Crit Rev Eukaryot Gene Expr. 2016; 26(4): 333-341. DOI: 10.1615/CritRevEukaryotGeneExpr.2016016859 Zhang L, Li Y, Guo Q, Duan Y, Wang W, Zhong Y, et al. Leucine supplementation: A novel strategy for modulating lipid metabolism and energy homeostasis. Nutrients. 2020; 12(5): 1299. DOI: 10.3390/nu12051299 Kouba M, and Mourot J. A review of nutritional effects on fat composition of animal products with special emphasis on n-3 polyunsaturated fatty acids. Biochimie. 2011; 93(1): 13-17. DOI: 10.1016/j.biochi.2010.02.027 Kuhla B, Metges CC, and Hammon HM. Endogenous and dietary lipids influencing feed intake and energy metabolism of periparturient dairy cows. Domest Anim Endocrinol. 2016; 56: S2-S10. DOI: 10.1016/j.domaniend.2015.12.002 Liu Y, Zhang H, Yang X, and Xie C. Dietary uridine improves lipid homeostasis in high-fat diet-induced obese mice by regulating liver gene expression and metabolomic profiles. Front Nutr. 2025; 12: 1651993. DOI: 10.3389/fnut.2025.1651993 Vasantha Rupasinghe HP, Sekhon-Loodu S, Mantso T, and Panayiotidis MI. Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss. Pharmacol Ther. 2016; 165: 153-163. DOI: 10.1016/j.pharmthera.2016.06.005 Luo Y, Cheng R, Liang H, Miao Z, Wang J, Zhou Q, et al. Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed Streptococcus thermophilus MN-ZLW-002. Exp Anim. 2022; 71(4): 468-480. DOI: 10.1538/expanim.21-0182 Jump DB, and Clarke SD. Regulation of gene expression by dietary fat. Annu Rev Nutr. 1999; 19: 63-90. DOI: 10.1146/annurev.nutr.19.1.63 Yan K. Recent advances in the effect of adipose tissue inflammation on insulin resistance. Cell Signal. 2024; 120: 111229. DOI: 10.1016/j.cellsig.2024.111229 Beaupere C, Liboz A, Fève B, Blondeau B, and Guillemain G. Molecular mechanisms of glucocorticoid-induced insulin resistance. Int J Mol Sci. 2021; 22(2): 623. DOI: 10.3390/ijms22020623 Singh V, Mahra K, Jung D, and Shin JH. Gut microbes in polycystic ovary syndrome and associated comorbidities; type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and the potential of microbial therapeutics. Probiotics Antimicrob Proteins. 2024; 16(5): 1744-1761. DOI: 10.1007/s12602-024-10262-y Sarwar H, Rafiqi SI, Ahmad S, Jinna S, Khan SA, Karim T, et al. Hyperinsulinemia associated depression. Clin Med Insights Endocrinol Diabetes. 2022; 15: 11795514221090244. DOI: 10.1177/11795514221090244 Zhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu DP, et al. Antioxidant Phytochemicals for the prevention and treatment of chronic diseases. molecules. 2015; 20(12): 21138-21156. DOI: 10.3390/molecules201219753 Kilwein MD, Dao TK, and Welte MA. Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis. PLoS Genet. 2023; 19(8): e1010875. DOI: 10.1371/journal.pgen.1010875 Jarc E, and Petan T. A twist of FATe: Lipid droplets and inflammatory lipid mediators. Biochimie. 2020; 169: 69-87. DOI: 10.1016/j.biochi.2019.11.016 de Andrade Melo-Sterza F, and Poehland R. Lipid metabolism in bovine oocytes and early embryos under in vivo, in vitro, and stress conditions. Int J Mol Sci. 2021; 22(7): 3421. DOI: 10.3390/ijms22073421 Tan Y, Jin Y, Wang Q, Huang J, Wu X, and Ren Z. Perilipin 5 protects against cellular oxidative stress by enhancing mitochondrial function in HepG2 cells. Cells. 2019; 8(10): 1241. DOI: 10.3390/cells8101241 Hussain SS, Tran TM, Ware TB, Luse MA, Prevost CT, Ferguson AN, et al. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal. Cell Rep. 2021; 36(4): 109451. DOI: 10.1016/j.celrep.2021.109451 Nerstedt A, Kurhe Y, Cansby E, Caputo M, Gao L, Vorontsov E, et al. Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver. J Lipid Res. 2020; 61(2): 178-191. DOI: 10.1194/jlr.RA119000316 Ralhan I, Chang CL, Lippincott-Schwartz J, and Ioannou MS. Lipid droplets in the nervous system. Lipid droplets in the nervous system. J Cell Biol. 2021; 220(7): e202102136. DOI: 10.1083/jcb.202102136 VandeKopple MJ, Wu J, Auer EN, Giaccia AJ, Denko NC, and Papandreou I. HILPDA regulates lipid metabolism, lipid droplet abundance, and response to microenvironmental stress in solid tumors. Mol Cancer Res. 2019; 17(10): 2089-2101. DOI: 10.1158/1541-7786.MCR-18-1343 Teixeira PG, David F, Siewers V, and Nielsen J. Engineering lipid droplet assembly mechanisms for improved triacylglycerol accumulation in Saccharomyces cerevisiae. FEMS Yeast Res. 2018; 18(6): foy060. DOI: 10.1093/femsyr/foy060 Wei C, Yan Y, Miao X, and Jiao R. Dissection and lipid droplet staining of oenocytes in Drosophila larvae. J Vis Exp. 2019; (154): e60606. DOI: 10.3791/60606 Rimkus SA, Ganetzky B, and Wassarman DA. Traumatic brain injury reprograms lipid droplet metabolism shaped by aging and diet in Drosophila brain. PLoS One. 2025; 20(9): e0332333. DOI: 10.1371/journal.pone.0332333 Bradley J, and Swann K. Mitochondria and lipid metabolism in mammalian oocytes and early embryos. Int J Dev Biol. 2019; 63(3-4-5): 93-103. DOI: 10.1387/ijdb.180355ks Asimakopoulou A, Borkham-Kamphorst E, Henning M, Yagmur E, Gassler N, Liedtke C, et al. Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. Biochim Biophys Acta. 2014; 1842(10): 1513-1524. DOI: 10.1016/j.bbalip.2014.07.017 Li M, Zhao B, Wang J, Zhang H, Yang Y, Song S, et al. Caveolin 1 in bovine liver is associated with fatty acid-induced lipid accumulation and the endoplasmic reticulum unfolded protein response: Role in fatty liver development. J Dairy Sci. 2025; 108(1): 1007-1021. DOI: 10.3168/jds.2024-25349 Ackerman D, Tumanov S, Qiu B, Michalopoulou E, Spata M, Azzam A, et al. Triglycerides promote lipid homeostasis during hypoxic stress by balancing fatty acid saturation. Cell Rep. 2018; 24(10): 2596-2605. DOI: 10.1016/j.celrep.2018.08.015 Li Y, De J, Jiang Q, Yang Y, Xu W, Du X, et al. Comparison of lipid metabolism between broodstock and hybrid offspring in the hepatopancreas of juvenile shrimp (Macrobrachium nipponense): Response to chronic ammonia stress. Anim Genet. 2022; 53(3): 393-404. DOI: 10.1111/age.13194 Fueser H, Majdi N, Haegerbaeumer A, Pilger C, Hachmeister H, Greife P, et al. Analyzing life-history traits and lipid storage using CARS microscopy for assessing effects of copper on the fitness of Caenorhabditis elegans. Ecotoxicol Environ Saf. 2018; 156: 255-262. DOI: 10.1016/j.ecoenv.2018.03.037 Abbink MR, Schipper L, Naninck EFG, de Vos CMH, Meier R, van Der Beek EM, et al. The effects of early life stress, postnatal diet modulation, and long-term Western-style diet on later-life metabolic and cognitive outcomes. Nutrients. 2020; 12(2): 570. DOI: 10.3390/nu12020570 Bisogno S, Depciuch J, Gulzar H, Heber MF, Kobiałka M, Gąsior Ł, et al. Female-age-dependent changes in the lipid fingerprint of the mammalian oocytes. Hum Reprod. 2024; 39(12): 2754-2767. DOI: 10.1093/humrep/deae225 Wang L, Lin J, Yu J, Yang K, Sun L, Tang H, et al. Downregulation of Perilipin1 by the Immune deficiency pathway leads to lipid droplet reconfiguration and adaptation to bacterial infection in Drosophila. J Immunol. 2021; 207(9): 2347-2358. DOI: 10.4049/jimmunol.2100343 Min L, Li D, Tong X, Nan X, Ding D, Xu B, et al. Nutritional strategies for alleviating the detrimental effects of heat stress in dairy cows: A review. Int J Biometeorol. 2019; 63(9): 1283-1302. DOI: 10.1007/s00484-019-01744-8 Sordillo LM, and Raphael W. Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders. Vet Clin North Am Food Anim Pract. 2013; 29(2): 267-278. DOI: 10.1016/j.cvfa.2013.03.002 Mohammed BM, Mohamed Ahmed IA, Alshammari GM, Osman MA, and Yahya MA. Fermented and germinated Samh seeds reduces hyperlipidemia, oxidative stress, and inflammation in rats fed a high-fat diet. Mol Nutr Food Res. 2025; 69(21): e70204. DOI: 10.1002/mnfr.70204 Sanchez-Roman I, and Barja G. Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction. Exp Gerontol. 2013; 48(10): 1030-1042. DOI: 10.1016/j.exger.2013.02.021 Popović T, Borozan S, Arsić A, Martačić JD, Vučić V, Trbović A, et al. Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male Wistar rats. J Anim Physiol Anim Nutr (Berl). 2012; 96(6): 1020-1029. DOI: 10.1111/j.1439-0396.2011.01216.x Yu BP, LIM BO, and SUGANO M. Dietary restriction downregulates free radical and lipid peroxide production: Plausible mechanism for elongation of life span. J Nutr Sci Vitaminol (Tokyo). 2002; 48(4): 257-264. DOI: 10.3177/jnsv.48.257 Ponnampalam EN, Kiani A, Santhiravel S, Holman BWB, Lauridsen C, and Dunshea FR. The importance of dietary antioxidants on oxidative stress, meat and milk production, and their preservative aspects in farm animals: Antioxidant action, animal health, and product quality – Invited Review. Animals. 2022; 12(23): 3279. DOI: 10.3390/ani12233279 Gao J, Ren H, Wu X, Zou C, He B, and Ma W. Dietary glycerol monolaurate mitigates heat stress-induced disruption of intestinal homeostasis and hepatic lipid metabolism in laying hens. Stress Biol. 2025; 5(1): 49. DOI: 10.1007/s44154-025-00243-8 Qi M, Wang J, Tan B, Li J, Liao S, Liu Y, and Yin Y. Dietary glutamine, glutamate, and aspartate supplementation improves hepatic lipid metabolism in post-weaning piglets. Anim Nutr. 2020; 6(2): 124-129. DOI: 10.1016/j.aninu.2019.12.002 Dasilva G, Pazos M, García-Egido E, Pérez-Jiménez J, Torres JL, Giralt MJ, et al. Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of metabolic syndrome using SHROB rats as a model. Food Chem. 2016; 205: 196-203. DOI: 10.1016/j.foodchem.2016.03.020 Hunsche C, de Toda IM, Hernandez O, Jiménez B, Díaz LE, Marcos A, et al. The supplementations with 2-hydroxyoleic acid and n-3 polyunsaturated fatty acids revert oxidative stress in various organs of diet-induced obese mice. Free Radic Res. 2020; 54(6): 455-466. DOI: 10.1080/10715762.2020.1800004 Lee J, Lee JK, Lee JJ, Park S, Jung S, Lee HJ, et al. Partial replacement of high-fat diet with beef tallow attenuates dyslipidemia and endoplasmic reticulum stress in db/db mice. J Med Food. 2022; 25(6): 660-674. DOI: 10.1089/jmf.2022.K.0019 Rincón-Cervera MA, Valenzuela R, Hernández-Rodas MC, Marambio M, Espinosa A, Mayer S, et al. Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues. Nutrition. 2016; 32(11-12): 1254-1267. DOI: 10.1016/j.nut.2016.04.006 Liu H, Nie C, Hu X, and Li J. Highland barley β-glucan supplementation attenuated hepatic lipid accumulation in Western diet-induced non-alcoholic fatty liver disease mice by modulating gut microbiota. Food Funct. 2024; 15(3): 1250-1264. DOI: 10.1039/d3fo03386d Dong Y, Li L, Xia T, Wang L, Xiao L, Ding N, et al. Oxidative stress can be attenuated by 4-PBA caused by high-fat or ammonia nitrogen in cultured spotted seabass: The mechanism is related to endoplasmic reticulum stress. Antioxidants. 2022; 11(7): 1276. DOI: 10.3390/antiox11071276 Yanguas-Casás N, Torres-Fuentes C, Crespo-Castrillo A, Diaz-Pacheco S, Healy K, Stanton CS, et al. High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner. Neurobiol Dis. 2021; 159: 105495. DOI: 10.1016/j.nbd.2021.105495 Chu MM, Luyer MDP, Wheelhouse NM, Bellamy CO, Greve JWM, Buurman WA, et al. Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat. World J Surg. 2007; 31(8): 1693-1701. DOI: 10.1007/s00268-007-9107-2 Khan MZ, Huang B, Kou X, Chen Y, Liang H, Ullah Q, et al. Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis. Front Immunol. 2024; 14: 1290044. DOI: 10.3389/fimmu.2023.1290044 Santamarina AB, Sertorio MN, Mennitti LV, de Souza EA, de Souza DV, Ribeiro DA, et al. Hepatic effects of low-carbohydrate diet associated with different lipid sources: Insights into oxidative stress, cytotoxicity, and epigenetic markers in a mouse model of obesity. J Nutr. 2024; 154(5): 1517-1531. DOI: 10.1016/j.tjnut.2024.04.007 Most MS, and Yates DT. Inflammatory mediation of heat stress-induced growth deficits in livestock and its potential role as a target for nutritional interventions: A review. Animals. 2021; 11(12): 3539. DOI: 10.3390/ani11123539 Wang L, Yang T, Pan Y, Shi L, Jin Y, and Huang X. The metabolism of reactive oxygen species and their effects on lipid biosynthesis of microalgae. Int J Mol Sci. 2023; 24(13): 11041. DOI: 10.3390/ijms241311041 Liu JL, and Hekimi S. The impact of mitochondrial oxidative stress on bile acid-like molecules in C. elegans provides a new perspective on human metabolic diseases. Worm. 2013; 2(1): e21457. DOI: 10.4161/worm.21457 Wang W, Gao X, Liu L, Guo S, Duan J, and Xiao P. Zebrafish as a vertebrate model for high-throughput drug toxicity screening: Mechanisms, novel techniques, and future perspectives. J Pharm Anal. 2025; 15(9): 101195. DOI: 10.1016/j.jpha.2025.101195 Min L, Zhao S, Tian H, Zhou X, Zhang Y, Li S, et al. Metabolic responses and “omics” technologies for elucidating the effects of heat stress in dairy cows. Int J Biometeorol. 2017; 61(6): 1149-1158. DOI: 10.1007/s00484-016-1283-z Rehman ZU, Meng C, Yingjie S, Safdar A, Pasha RH, Munir M, , et al. Oxidative stress in poultry: Lessons from the viral infections. Oxid Med Cell Longev. 2018; 2018(1): 5123147. DOI: 10.1155/2018/5123147 Karnati S, and Baumgart-Vogt E. Peroxisomes in airway epithelia and future prospects of these organelles for pulmonary cell biology. Histochem Cell Biol. 2009; 131(4): 447-454. DOI: 10.1007/s00418-009-0566-4 Estévez M, and Xiong Y. Intake of oxidized proteins and amino acids and causative oxidative stress and disease: Recent scientific evidences and hypotheses. J Food Sci. 2019; 84(3): 387-396. DOI: 10.1111/1750-3841.14460 Cheah LT, Hindle MS, Khalil JS, Duval C, Unsworth AJ, and Naseem KM. Cells. 2025; 14(7): 500. DOI: 10.3390/cells14070500 ang SY, and Choi KM. Impact of adipose tissue and lipids on skeletal muscle in sarcopenia. J Cachexia Sarcopenia Muscle. 2025; 16(4): e70000. DOI: 10.1002/jcsm.70000 Min L, Cheng J, Zhao S, Tian H, Zhang Y, Li S, et al. Plasma-based proteomics reveals immune response, complement and coagulation cascades pathway shifts in heat-stressed lactating dairy cows. J Proteomics. 2016; 146: 99-108. DOI: 10.1016/j.jprot.2016.06.008 Pevzner IB, Andrianova NV, Lomakina AK, Cherkesova KS, Semenchenko ED, and Plotnikov EY. Organ-specific extracellular vesicles in the treatment of ischemic acute organ injury: Mechanisms, successes, and prospects. Int J Mol Sci. 2025; 26(19): 9709. DOI: 10.3390/ijms26199709 Akash MSH, Yaqoob A, Rehman K, Imran M, Assiri MA, Al-Rashed F, et al. Metabolomics: A promising tool for deciphering metabolic impairment in heavy metal toxicities. Front Mol Biosci. 2023; 10: 1218497. DOI: 10.3389/fmolb.2023.1218497 Ducret V, Richards AJ, Videlier M, Scalvenzi T, Moore KA, Paszkiewicz K, et al. Transcriptomic analysis of the trade-off between endurance and burst-performance in the frog Xenopus allofraseri. BMC Genomics. 2021; 22(1): 204. DOI: 10.1186/s12864-021-07517-1 Loor JJ. Genomics of metabolic adaptations in the peripartal cow. Animal. 2010; 4(7): 1110-1139. DOI: 10.1017/S1751731110000960