eng Rovedar Small Animal Advances 2821-2363 2026-03-31 5 1 5 15 10.58803/saa.v5i1.47 49 Muhammad Hanzalah Yousaf 0 https://orcid.org/0009-0005-7241-5701 Umar Aziz 0 https://orcid.org/0009-0009-6266-4340 Abdul Rehman 1 https://orcid.org/0009-0009-3221-2984 Muhammad Waqar 0 https://orcid.org/0009-0001-0172-9739 Nimra Safdar Ali 2 https://orcid.org/0009-0000-6141-0917 Nauman Khan 0 https://orcid.org/0009-0008-1289-6859 Muhammad Mohsin 0 https://orcid.org/0009-0004-8057-9303 Muhammad Yahya Maarij 3 https://orcid.org/0009-0003-1031-2964 Muhammad Mushahid 4 https://orcid.org/0000-0001-8670-3011 Xiaopeng An 0 College of Animal Science and Technology, Northwest A&F University, Yangling, China Faculty of Animal Production and Technology, Cholistan University of Veterinary & Animal Sciences, Punjab, Pakistan Institute of Animal and Dairy Sciences, Faculty of Animal Husbandry, University of Agriculture Faisalabad, Punjab, Pakistan Canterbury Christ Church University, North Holmes Road, Canterbury, England University of Agriculture Faisalabad, Constituent College Toba Tek Singh, Toba Tek Singh, Punjab, Pakistan Lipids are essential for animal physiology; however, dysregulated lipid metabolism can induce metabolic stress and impair growth, development, and reproduction. Metabolic homeostasis depends on endocrine-immune system interactions, yet how lipid droplets and organelles, such as the endoplasmic reticulum, mitochondria, lysosomes, and peroxisomes, contribute to stress‑induced lipid dysregulation remains unclear. The present study aimed to synthesize current evidence on redox-mediated regulation of lipid metabolism and lipid metabolic disorders in animals, highlighting recent advances, and identify key directions for future studies. The present study summarized evidence on how different dietary lipid classes influence metabolism and animal health, as well as the role of bioactive nutrients in metabolic programming. The current study described the endocrine functions of the liver, gut, and adipose tissue, as well as the stress-related interactions among these organs. The present study indicated how lipid droplets engaged in dynamic organelle interactions during stress progression and evaluated the potential of lipid‑focused nutritional interventions as personalized mitigation strategies. In addition, gut microbiota-derived metabolites and related pathways that contribute to redox imbalance, organelle dysfunction, and stress-associated lipid dysregulation were explored. The current study demonstrated that stress-induced disruptions in lipid metabolism involve intricate, multi-organ, and multi-organelle mechanisms driven by redox changes. https://saa.rovedar.com/index.php/SAA/article/view/47 Gut microbiota Lipid droplet Lipid metabolism Metabolic disorder Oxidative stress Redox signaling